Systemic Lupus Erythematosus Presenting With Posterior Reversible Encephalopathy Syndrome: An Unusual Case

Posterior reversible encephalopathy syndrome (PRES) has been reported in association with hypertension, renal failure, transplantation and immunosuppressives [1]. However, reports of PRES in conjunction with SLE are sparse [2]. Majority of these patients had lupus nephritis and hypertension [3]. Recent reports have shown a stringent association of PRES with hypertension in SLE patients and response to cyclophosphamide-methylprednisolone pulse therapy [4]. Here, we report a rare case of a normotensive patient of SLE presenting with PRES. The patient was treatment-naïve and had significant renal involvement. Her neurologic impairment and overall disease activity improved following treatment with pulse doses of immunosuppressives.